Brain Pharm: Brain Pharmacology Database User: Public
SenseLab  Home Data Search Schema Login	[Data] Pathological mechanism Name beta-amyloid reduces IA Description Bicuculline and DNQX used to silent synapses Hypothesis Dendritic Hypothesis - K+ current   show other Extracelular pathological element β-Amyloid   show other Intracelular pathological element Pathological action Inhibits   show other Process Process action Transmitter(s) Receptor(s) Channel(s) I A   show other Pharmacological Agent Pharmacological Action Brain region Hippocampus   show other Neuron CA1 pyramidal neuron   show other Cell model Cellular compartment Soma   show other Dendrite   show other PubMed ID 16289381 Citation 16289381   show other AlzWeb Notes Application of beta-amyloid to outside-out patches reduces the A-current; leading to increased dendritic calcium influx and loss of calcium homeostasis, potentially causing synaptic failure and initiating neuronal degenerative proceses(Chen C 2005). Pathology Alzheimer   show other Stage Early   show other Question Claim Aß influences neuronal excitability by effects on dendritic ion channels   show other Soluble Aß affects CA1 Hippocampal neurons by action on A-type channels   show other A-type K+ channel block causes increased back-propagation of action potentials   show other Other categories referring to "beta-amyloid reduces IA"   Revisions: 16 Last time: 3/20/2009 2:36:38 PM Reviewer: EAV/CR Schema Administrator Owner: EAV/CR Schema Administrator
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