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SenseLab  Home Data Search Schema Login	[Data] Computational model Name Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008) Model File XuClancy2008 [? bytes] Notes "... We present a single-compartment model of a CA3 hippocampal pyramidal neuron based on recent experimental data. We then use the model to determine the roles of primary depolarizing currents in burst generation. The single compartment model incorporates accurate representations of sodium (Na+) channels (NaV1.1) and T-type calcium (Ca2+) channel subtypes (CaV3.1, CaV3.2, and CaV3.3). Our simulations predict the importance of Na+ and T-type Ca2+ channels in hippocampal pyramidal cell bursting and reveal the distinct contribution of each subtype to burst morphology. We also performed fastslow analysis in a reduced comparable model, which shows that our model burst is generated as a result of the interaction of two slow variables, the T-type Ca2+ channel activation gate and the Ca2+-dependent potassium (K+) channel activation gate. The model reproduces a range of experimentally observed phenomena including afterdepolarizing potentials, spike widening at the end of the burst, and rebound. Finally, we use the model to simulate the effects of two epilepsy-linked mutations: R1648H in NaV1.1 and C456S in CaV3.2, both of which result in increased cellular excitability." Model Neurons CA3 pyramidal neuron   show other More Cells Model Currents I K   show other I K,Ca   show other I L high threshold   show other I M   show other I N   show other I Calcium   show other I A   show other I Na,t   show other I T low threshold   show other Model Receptors GabaB   show other Model Type Neuron or other electrically excitable cell   show other Model Concept Bursting   show other Ion Channel Kinetics   show other Model papers Xu J, Clancy CE (2008)   show other Simulator software C or C++ program   show other Gene Cav3.1 CACNA1G   show other Cav3.2 CACNA1H   show other Cav3.3 CACNA1I   show other Nav1.1 SCN1A   show other hg folder name (applicable when in ModelDB hg) Region Organism Model ID Number Gap Junctions Implemented by Read write access code Public Submitter Email Address tom.morse@yale.edu Model Neurotransmitters Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Alternative Version Citation Default File Notes Other Gene Simulation Platform ID 65 Has Model View 0 Other categories referring to "Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008)"   Revisions: 4 Last time: 7/13/2009 11:31:33 AM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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