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SenseLab  Home Data Search Schema Login	[Data] Computational model Name Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008) Model File RoyeckEtAl2008 [? bytes] Notes "... We show that the Na+ channel NaV1.6 displays a striking aggregation at the AIS of cortical neurons. ... In combination with simulations using a realistic computer model of a CA1 pyramidal cell, our results imply that a hyperpolarized voltage-dependence of activation of AIS NaV1.6 channels is important both in determining spike threshold and localizing spike initiation to the AIS. ... These results suggest that NaV1.6 subunits at the AIS contribute significantly to its role as spike trigger zone and shape repetitive discharge properties of CA1 neurons." Model Neurons CA1 pyramidal neuron   show other More Cells Model Currents I A   show other I Q   show other I p,q   show other I T low threshold   show other I Na,t   show other I Na,p   show other I N   show other I M   show other I L high threshold   show other I Calcium   show other I h   show other I K   show other I K,Ca   show other Model Receptors Model Type Neuron or other electrically excitable cell   show other Model Concept Temporal Pattern Generation   show other Ion Channel Kinetics   show other Action Potential Initiation   show other Model papers Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008)   show other Simulator software Neuron   show other Gene Nav1.6 SCN8A   show other hg folder name (applicable when in ModelDB hg) Region Organism Hippocampus   show other Model ID Number Gap Junctions Implemented by Horstmann, Marie-Therese [mhorstma at uni-bonn.de]   show other Read write access code Public Submitter Email Address tom.morse@yale.edu Model Neurotransmitters Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Alternative Version Citation Default File Notes Other Gene Simulation Platform ID 157 Has Model View 0 Other categories referring to "Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)"   Revisions: 11 Last time: 11/23/2009 11:39:59 AM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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