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SenseLab  Home Data Search Schema Login	[Data] Computational model Name Multicompartmental cerebellar granule cell model (Diwakar et al. 2009) Model File GrC [? bytes] Notes A detailed multicompartmental model was used to study neuronal electroresponsiveness of cerebellar granule cells in rats. Here we show that, in cerebellar granule cells, Na+ channels are enriched in the axon, especially in the hillock, but almost absent from soma and dendrites. Numerical simulations indicated that granule cells have a compact electrotonic structure allowing EPSPs to diffuse with little attenuation from dendrites to axon. The spike arose almost simultaneously along the whole axonal ascending branch and invaded the hillock, whose activation promoted spike back-propagation with marginal delay (<200 micros) and attenuation (<20 mV) into the somato-dendritic compartment. For details check the cited article. Model Neurons Cerebellar granule cell   show other More Cells Model Currents I A, slow   show other I Calcium   show other I Sodium   show other I K,Ca   show other I M   show other I Potassium   show other I A   show other I h   show other Model Receptors Model Type Neuron or other electrically excitable cell   show other Model Concept Action Potential Initiation   show other Action Potentials   show other Active Dendrites   show other Axonal Action Potentials   show other Detailed Neuronal Models   show other Synaptic modulation of active currents   show other Model papers Diwakar S, Magistretti J, Goldfarb M, Naldi G, D`Angelo E (2009)   show other Simulator software Neuron   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Cerebellum   show other Model ID Number Gap Junctions Implemented by Diwakar, Shyam [shyam at amrita.edu]   show other Read write access code Public Submitter Email Address Model Neurotransmitters Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Diwakar, Shyam shyam@unipv.it Alternative Version Citation Default File Notes Other Gene Simulation Platform ID 287 Has Model View 0 Other categories referring to "Multicompartmental cerebellar granule cell model (Diwakar et al. 2009)"   Revisions: 11 Last time: 4/6/2009 2:18:52 PM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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