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Computational model
NameAvailability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003)
Model File
leeEtAl2003 [? bytes]
Notes"... we measured T-type current of isolated goldfish retinal ganglion cells with perforated-patch voltageclamp methods in solutions containing a normal extracellular Ca2+ concentration. The voltage sensitivities and rates of current activation, inactivation, deactivation, and recovery from inactivation were similar to those of expressed +1G (CaV3.1) Ca2+ channel clones, except that the rate of deactivation was significantly faster. We reproduced the amplitude and kinetics of measured T currents with a numerical simulation based on a kinetic model developed for an +1G Ca2+ channel. Finally, we show that this model predicts the increase of T-type current made available between resting potential and spike threshold by repetitive hyperpolarizations presented at rates that are within the bandwidth of signals processed in situ by these neurons."
Model Neurons
Retina ganglion cell show other
More Cells
Model Currents
I T low threshold show other
Model Receptors
Model Type
Neuron or other electrically excitable cell show other
Channel show other
Model Concept
Ion Channel Kinetics show other
Simulator software
NEURON show other
Model papers
Lee SC, Hayashida Y, Ishida AT (2003) show other
hg folder name (applicable when in ModelDB hg)
Gene
Cav3.1 CACNA1G show other
Region Organism
Retina show other
Gap Junctions
Model ID Number
Implemented by
Hayashida, Yuki [yukih at cs.kumamoto-u.ac.jp] show other
Read write access code
Public Submitter Email Addressthomas.morse@snet.net
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Model Neurotransmitters
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Other Neurotransmitter
Other Model TypeMarkovian kinetic model
Other Conceptrebound excitation
Other Simulator
Other Implementer
Alternative Version
Citation
Default File Notes
Other Gene
Simulation Platform ID156
Has Model View -1
Component
RAM
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Last time:1/20/2014 3:54:43 PM
Reviewer:Robert A McDougal
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