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SenseLab  Home Data Search Schema Login	[Data] Computational model Name Availability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003) Model File leeEtAl2003 [? bytes] Notes "... we measured T-type current of isolated goldfish retinal ganglion cells with perforated-patch voltageclamp methods in solutions containing a normal extracellular Ca2+ concentration. The voltage sensitivities and rates of current activation, inactivation, deactivation, and recovery from inactivation were similar to those of expressed +1G (CaV3.1) Ca2+ channel clones, except that the rate of deactivation was significantly faster. We reproduced the amplitude and kinetics of measured T currents with a numerical simulation based on a kinetic model developed for an +1G Ca2+ channel. Finally, we show that this model predicts the increase of T-type current made available between resting potential and spike threshold by repetitive hyperpolarizations presented at rates that are within the bandwidth of signals processed in situ by these neurons." Model Neurons Retinal ganglion cell   show other More Cells Model Currents I T low threshold   show other Model Receptors Model Type Channel   show other Neuron or other electrically excitable cell   show other Model Concept Ion Channel Kinetics   show other Model papers Lee SC, Hayashida Y, Ishida AT (2003)   show other Simulator software Neuron   show other Gene Cav3.1 CACNA1G   show other hg folder name (applicable when in ModelDB hg) Region Organism Retina   show other Model ID Number Gap Junctions Implemented by Hayashida, Yuki [yukih at cs.kumamoto-u.ac.jp]   show other Read write access code Public Submitter Email Address thomas.morse@snet.net Model Neurotransmitters Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Markovian kinetic model Other Concept rebound excitation Other Simulator Other Implementer Alternative Version Citation Default File Notes Other Gene Simulation Platform ID 156 Has Model View 0 Other categories referring to "Availability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003)"   Revisions: 5 Last time: 12/7/2009 3:12:03 PM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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