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SenseLab  Home Data Search Schema Login	[Data] Computational model Name A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity (Nakano et al. 2010) Model File Plos_model [? bytes] Notes A signaling pathway model of spines that express D1-type dopamine receptors was constructed to analyze the dynamic mechanisms of dopamine- and calcium-dependent plasticity. The model incorporated all major signaling molecules, including dopamine- and cyclic AMP-regulated phosphoprotein with a molecular weight of 32 kDa (DARPP32), as well as AMPA receptor trafficking in the post-synaptic membrane. Simulations with dopamine and calcium inputs reproduced dopamine- and calcium-dependent plasticity. Further in silico experiments revealed that the positive feedback loop consisted of protein kinase A (PKA), protein phosphatase 2A (PP2A), and the phosphorylation site at threonine 75 of DARPP-32 (Thr75) served as the major switch for inducing LTD and LTP. The present model elucidated the mechanisms involved in bidirectional regulation of corticostriatal synapses and will allow for further exploration into causes and therapies for dysfunctions such as drug addiction." Model Neurons Neostriatal spiny neuron   show other More Cells Model Currents Model Receptors Dopaminergic Receptor   show other Model Type Molecular Network   show other Synapse   show other Model Concept Signaling pathways   show other Model papers Nakano T, Doi T, Yoshimoto J, Doya K (2010)   show other Simulator software GENESIS   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Basal ganglia   show other Model ID Number Gap Junctions Implemented by Nakano, Takashi [nakano.takashi at gmail.com]   show other Read write access code Public Submitter Email Address nakano.takashi@gmail.com Model Neurotransmitters Dopamine   show other Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Nakano, Takashi Alternative Version Citation PMID: 20169176 Default File Notes Other Gene Simulation Platform ID Has Model View 0 Other categories referring to "A kinetic model of dopamine- and calcium-dependent striatal synaptic plasticity (Nakano et al. 2010)"   Revisions: 6 Last time: 9/5/2012 1:37:30 PM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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