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SenseLab  Home Data Search Schema Login	[Data] Computational model Name NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010) Model File withdrawal_r2 [? bytes] Notes Cannabinoid withdrawal produces a hypofunction of dopaminergic neurons targeting medium spiny neurons (MSN) of the forebrain. Administration of a CB1 receptor antagonist to control rats provoked structural abnormalities, reminiscent of those observed in withdrawal conditions and support the regulatory role of cannabinoids in neurogenesis, axonal growth and synaptogenesis. Experimental observations were incorporated into a realistic computational model which predicts a strong reduction in the excitability of morphologically-altered MSN, yielding a significant reduction in action potential output. These paper provided direct morphological evidence for functional abnormalities associated with cannabinoid dependence at the level of dopaminergic neurons and their post synaptic counterpart, supporting a hypodopaminergic state as a distinctive feature of the “addicted brain”. Model Neurons More Cells Nucleus accumbens medium spiny projection neuron   show other Model Currents I A   show other I A, slow   show other I Na,t   show other I Potassium   show other I Krp   show other Model Receptors AMPA   show other Model Type Dendrite   show other Model Concept Action Potential Initiation   show other Action Potentials   show other Synaptic Integration   show other Detailed Neuronal Models   show other Addiction   show other Activity Patterns   show other Active Dendrites   show other Model papers Spiga S, Lintas A, Migliore M, Diana M (2010)   show other Simulator software Neuron   show other Gene hg folder name (applicable when in ModelDB hg) withdrawal Region Organism Basal ganglia   show other Model ID Number Gap Junctions Implemented by Migliore, Michele [Michele.Migliore at Yale.edu]   show other Read write access code Public Submitter Email Address Model Neurotransmitters Glutamate   show other Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Alternative Version Citation Default File Notes Other Gene Simulation Platform ID 290 Has Model View 0 Other categories referring to "NAcc medium spiny neuron: effects of cannabinoid withdrawal (Spiga et al. 2010)"   Revisions: 9 Last time: 11/22/2011 11:18:10 AM Reviewer: Tom Morse - MoldelDB admin Owner: Michele Migliore
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