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Computational model
NameAction potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010)
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Notes"In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na+ channels in the AIS. However, we found that action potential–associated Na+ flux, as measured by high-speed fluorescence Na+ imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na+ flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. ... In computer simulations, these data were consistent with the known features of action potential generation in these neurons."
Model Neurons
Neocortex pyramidal layer 5-6 cell show other
Neocortex pyramidal layer 2-3 cell show other
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Model Currents
I Na,t show other
I K show other
Model Receptors
Model Type
Neuron or other electrically excitable cell show other
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Simplified Models show other
Active Dendrites show other
Action Potentials show other
Simulator software
NEURON show other
Model papers
Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) show other
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Region Organism
Neocortex show other
Gap Junctions
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Implemented by
Fleidervish, Ilya [ilya.fleidervish at gmail.com] show other
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Public Submitter Email Addresstom.morse@yale.edu
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Alternative Version
Citation20543843
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RAM
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Last time:1/6/2011 4:25:14 PM
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