ModelDB: Model Database User: Public
Skip Navigation Links
Computational model
NameAction potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010)
Model File
Notes"In cortical pyramidal neurons, the axon initial segment (AIS) is pivotal in synaptic integration. It has been asserted that this is because there is a high density of Na+ channels in the AIS. However, we found that action potential–associated Na+ flux, as measured by high-speed fluorescence Na+ imaging, was about threefold larger in the rat AIS than in the soma. Spike-evoked Na+ flux in the AIS and the first node of Ranvier was similar and was eightfold lower in basal dendrites. ... In computer simulations, these data were consistent with the known features of action potential generation in these neurons."
Model Neurons
Neocortex layer 5-6 pyramidal cell show other
Neocortex layer 2-3 pyramidal cell show other
More Cells
Model Currents
I Na,t show other
I K show other
Model Receptors
Model Type
Neuron or other electrically excitable cell show other
Model Concept
Simplified Models show other
Active Dendrites show other
Action Potentials show other
Simulator software
NEURON show other
Model papers
Fleidervish IA, Lasser-Ross N, Gutnick MJ, Ross WN (2010) show other
hg folder name (applicable when in ModelDB hg)
Region Organism
Neocortex show other
Gap Junctions
Model ID Number
Implemented by
Fleidervish, Ilya [ilya.fleidervish at] show other
Read write access code
Public Submitter Email
Model Neurotransmitters
Other Neuron
Other Receptor
Other Current
Other Neurotransmitter
Other Model Type
Other Concept
Other Simulator
Other Implementer
Alternative Version
Default File Notes
Other Gene
Simulation Platform ID
Has Model View -1
Hide Auto-launch button 0
Run Protocols
136715_4 show other
136715_2 show other
136715_3 show other
136715_1 show other

Other categories referring to "Action potential-evoked Na+ influx are similar in axon and soma (Fleidervish et al. 2010)"

Last time:1/2/2015 10:34:01 PM
Reviewer:Robert A McDougal
Owner:Tom Morse - MoldelDB admin
Yale Center for Medical Informatics Questions, comments, problems? Email the Database Administrator
This site is Copyright 2015, Yale Center for Medical Informatics