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SenseLab  Home Data Search Schema Login	[Data] Computational model Name CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011) Model File Schizophr [? bytes] Notes NEURON files from the paper: A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. by M. Migliore, I. De Blasi, D. Tegolo, R. Migliore, Neural Networks,(2011), doi:10.1016/j.neunet.2011.01.001. Starting from the experimentally supported assumption on hippocampal neurons we explore an experimentally testable prediction at the single neuron level. The model shows how and to what extent a pathological hypofunction of a contextdependent distal input on a CA1 neuron can generate hallucinations by altering the normal recall of objects on which the neuron has been previously tuned. The results suggest that a change in the context during the recall phase may cause an occasional but very significant change in the set of active dendrites used for features recognition, leading to a distorted perception of objects. Model Neurons CA1 pyramidal neuron   show other More Cells Model Currents I Na,t   show other I Potassium   show other I K   show other I A   show other I h   show other Model Receptors AMPA   show other Model Type Dendrite   show other Model Concept Coincidence Detection   show other Dendritic Action Potentials   show other Detailed Neuronal Models   show other Influence of Dendritic Geometry   show other Synaptic Integration   show other Active Dendrites   show other Action Potentials   show other Schizophrenia   show other Model papers Migliore M, De Blasi I, Tegolo D, Migliore R (2011)   show other Simulator software Neuron   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Hippocampus   show other Model ID Number Gap Junctions Implemented by Migliore, Michele [Michele.Migliore at Yale.edu]   show other Read write access code Public Submitter Email Address michele.migliore@pa.ibf.cnr.it Model Neurotransmitters Glutamate   show other Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Alternative Version Citation Migliore M, De Blasi I, Tegolo D, Migliore R (2011) A modeling study suggesting how a reduction in the context-dependent input on CA1 pyramidal neurons could generate schizophrenic behavior. Neural Networks, doi:10.1016/j.neunet.2011.01.001 Default File Notes Other Gene Simulation Platform ID Has Model View 0 Other categories referring to "CA1 pyramidal neuron: schizophrenic behavior (Migliore et al. 2011)"   Revisions: 12 Last time: 3/31/2011 3:10:14 PM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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