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SenseLab  Home Data Search Schema Login	[Data] Computational model Name CN pyramidal fusiform cell (Kanold, Manis 2001) Model File CN_Pyr [? bytes] Notes Pyramidal cells in the dorsal cochlear nucleus (DCN) show three characteristic discharge patterns in response tones: pauser, buildup, and regular firing. Experimental evidence suggests that a rapidly inactivating K+ current (I(KIF)) plays a critical role in generating these discharge patterns. To explore the role of I(KIF), we used a computational model based on the biophysical data. The model replicated the dependence of the discharge pattern on the magnitude and duration of hyperpolarizing prepulses, and I(KIF) was necessary to convey this dependence. Experimentally, half-inactivation voltage and kinetics of I(KIF) show wide variability. Varying these parameters in the model ... suggests that pyramidal cells can adjust their sensitivity to different temporal patterns of inhibition and excitation by modulating the kinetics of I(KIF). Overall, I(KIF) is a critical conductance controlling the excitability of DCN pyramidal cells. (See readme.txt and paper for details). Any questions regarding these implementations should be directed to: pmanis@med.unc.edu 2 April 2004 Paul B Manis, Ph.D. Model Neurons CN pyramidal (fusiform) cell   show other More Cells Model Currents I h   show other I K   show other I Potassium   show other I Sodium   show other Model Receptors Model Type Neuron or other electrically excitable cell   show other Model Concept Temporal Pattern Generation   show other Activity Patterns   show other Synaptic Integration   show other Model papers Kanold PO, Manis PB (2001)   show other Kanold PO, Manis PB (1999)   show other Simulator software Neuron   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Model ID Number Gap Junctions Implemented by Manis, Paul B [PManis at med.unc.edu]   show other Read write access code Public Submitter Email Address Model Neurotransmitters Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Alternative Version Citation Default File Notes Other Gene Simulation Platform ID 187 Has Model View 0 Other categories referring to "CN pyramidal fusiform cell (Kanold, Manis 2001)"   Revisions: 16 Last time: 2/20/2006 9:56:21 AM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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