ModelDB: Model Database User: Public
SenseLab  Home Data Search Schema Login	[Data] Computational model Name Effects of Acetyl-L-carnitine on neural transmission (Lombardo et al 2004) Model File Leech_T_Cell_ALC [? bytes] Notes Acetyl-L-carnitine is known to improve many aspects of the neural activity even if its exact role in neurotransmission is still unknown. This study investigates the effects of acetyl-L-carnitine in T segmental sensory neurons of the leech Hirudo medicinalis. These neurons are involved in some forms of neural plasticity associated with learning processes. Their physiological firing is accompanied by a large afterhyperpolarization that is mainly due to the Na+/K+ ATPase activity and partially to a Ca2+-dependent K+ current. A clear-cut hyperpolarization and a significant increase of the afterhyperpolarization have been recorded in T neurons of leeches injected with 2 mM acetyl-L-carnitine some days before. Acute treatments of 50 mM acetyl-L-carnitine induced similar effects in T cells of naive animals. Moreover, in these cells, widely arborized, the afterhyperpolarization seems to play an important role in determining the action potential transmission at neuritic bifurcations. A computational model of a T cell has been previously developed considering detailed data for geometry and the modulation of the pump current. Herein, we showed that to a larger afterhyperpolarization, due to the acetyl-L-carnitine-induced effects, corresponds a decrement in the number of action potentials reaching synaptic terminals. Model Neurons More Cells Leech T segmental sensory neuron   show other Model Currents I Sodium   show other I Potassium   show other I L high threshold   show other Na/K pump   show other I K,Ca   show other Model Receptors Model Type Electrogenic pump   show other Neuron or other electrically excitable cell   show other Model Concept Sodium pump   show other Invertebrate   show other Axonal Action Potentials   show other Action Potentials   show other Activity Patterns   show other Model papers Lombardo P, Scuri R, Cataldo E, Calvani M, Nicolai R, Mosconi L, Brunelli M (2004)   show other Simulator software SNNAP   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Model ID Number Gap Junctions Gap junctions   show other Implemented by Read write access code Public Submitter Email Address Model Neurotransmitters Other Neuron Leech T cell Other Receptor Other Current I Leak, I Na Pump Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Cataldo, Enrico Alternative Version Citation Default File Notes Other Gene Simulation Platform ID Has Model View 0 Other categories referring to "Effects of Acetyl-L-carnitine on neural transmission (Lombardo et al 2004)"   Revisions: 17 Last time: 5/28/2009 1:07:07 PM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
	Questions, comments, problems? Email the Database Administrator This site is Copyright 2010, Yale Center for Medical Informatics