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SenseLab  Home Data Search Schema Login	[Data] Computational model Name Inhibitory control by an integral feedback signal in prefrontal cortex (Miller and Wang 2006) Model File weblink2_miller_wang2006 [? bytes] Notes The prefrontal cortex (PFC) is known to be critical for inhibitory control of behavior, but the underlying mechanisms are unclear. Here, we propose that inhibitory control can be instantiated by an integral signal derived from working memory, another key function of the PFC. Specifically, we assume that an integrator converts excitatory input into a graded mnemonic activity that provides an inhibitory signal (integral feedback control) to upstream afferent neurons. We demonstrate this scenario in a neuronal-network model for a temporal discrimination task... See paper for details and more. Model Neurons More Cells Model Currents Model Receptors Model Type Network   show other Model Concept Working memory   show other Simplified Models   show other Pattern Recognition   show other Activity Patterns   show other Action Selection/Decision Making   show other Model papers Miller P, Wang XJ (2006)   show other Simulator software C or C++ program (web link to model)   show other XPP   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Prefrontal cortex (PFC)   show other Neocortex   show other Model ID Number Gap Junctions Implemented by Miller, Paul [pmiller at brandeis.edu]   show other Read write access code Public Submitter Email Address Model Neurotransmitters Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Alternative Version backup of web link model   show other Citation Default File Notes Other Gene Simulation Platform ID Has Model View 0 Other categories referring to "Inhibitory control by an integral feedback signal in prefrontal cortex (Miller and Wang 2006)"   Revisions: 17 Last time: 1/15/2013 10:35:45 AM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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