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SenseLab  Home Data Search Schema Login	[Data] Computational model Name A dynamical model of the basal ganglia (Leblois et al 2006) Model File code [? bytes] Notes We propose a new model for the function and dysfunction of the basal ganglia (BG). The basal ganglia are a set of cerebral structures involved in motor control which dysfunction causes high-incidence pathologies such as Parkinson's disease (PD). Their precise motor functions remain unknown. The classical model of the BG that allowed for the discovery of new treatments for PD seems today outdated in several respects. Based on experimental observations, our model proposes a simple dynamical framework for the understanding of how BG may select motor programs to be executed. Moreover, we explain how this ability is lost and how tremor-related oscillations in neuronal activity may emerge in PD. Model Neurons More Cells Model Currents Model Receptors Model Type Connectionist Network   show other Model Concept Parkinson's   show other Pathophysiology   show other Rate-coding model neurons   show other Oscillations   show other Simplified Models   show other Spatio-temporal Activity Patterns   show other Model papers Leblois A, Boraud T, Meissner W, Bergman H, Hansel D (2006)   show other Simulator software C or C++ program   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Basal ganglia   show other Model ID Number Gap Junctions Implemented by Leblois, Arthur [leblois at clipper.ens.fr]   show other Read write access code Public Submitter Email Address leblois@clipper.ens.fr Model Neurotransmitters Other Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Leblois, arthur Alternative Version Citation Default File Notes Other Gene Simulation Platform ID 58 Has Model View 0 Other categories referring to "A dynamical model of the basal ganglia (Leblois et al 2006)"   Revisions: 8 Last time: 10/7/2008 9:19:15 AM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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