ModelDB: Model Database User: Public
SenseLab  Home Data Search Schema Login	[Data] Computational model Name Cardiac Atrial Cell (Courtemanche et al 1998) (C++) Model File HAM_AP [? bytes] Notes The mechanisms underlying many important properties of the human atrial action potential (AP) are poorly understood. Using specific formulations of the K+, Na+, and Ca2+ currents based on data recorded from human atrial myocytes, along with representations of pump, exchange, and background currents, we developed a mathematical model of the AP. The model AP resembles APs recorded from human atrial samples and responds to rate changes, L-type Ca2+ current blockade, Na+/Ca2+ exchanger inhibition, and variations in transient outward current amplitude in a fashion similar to experimental recordings. Rate-dependent adaptation of AP duration, an important determinant of susceptibility to atrial fibrillation, was attributable to incomplete L-type Ca2+ current recovery from inactivation and incomplete delayed rectifier current deactivation at rapid rates. Experimental observations of variable AP morphology could be accounted for by changes in transient outward current density, as suggested experimentally. We conclude that this mathematical model of the human atrial AP reproduces a variety of observed AP behaviors and provides insights into the mechanisms of clinically important AP properties. Model Neurons More Cells Model Currents I Na,t   show other I L high threshold   show other I K   show other I Calcium   show other Na/K pump   show other I Sodium   show other I Potassium   show other Model Receptors Model Type Electrogenic pump   show other Neuron or other electrically excitable cell   show other Model Concept Sodium pump   show other Pathophysiology   show other Ion Channel Kinetics   show other Heart disease   show other Action Potentials   show other Model papers Courtemanche M, Ramirez RJ, Nattel S (1998)   show other Simulator software C or C++ program   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Model ID Number Gap Junctions Implemented by Lai, Hsing-Jung   show other Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]   show other Read write access code Public Submitter Email Address snwu@mail.ncku.edu.tw Model Neurotransmitters Acetylcholine   show other Other Neuron heart cell Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Hsing-Jung Lai Alternative Version Citation Default File Notes Other Gene Simulation Platform ID Has Model View 0 Other categories referring to "Cardiac Atrial Cell (Courtemanche et al 1998) (C++)"   Revisions: 7 Last time: 5/28/2009 2:47:41 PM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
	Questions, comments, problems? Email the Database Administrator This site is Copyright 2010, Yale Center for Medical Informatics