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SenseLab  Home Data Search Schema Login	[Data] Computational model Name Homosynaptic plasticity in the tail withdrawal circuit (TWC) of Aplysia (Baxter and Byrne 2006) Model File Baxter_Byrne_Neurocomput_06 [? bytes] Notes The tail-withdrawal circuit of Aplysia provides a useful model system for investigating synaptic dynamics. Sensory neurons within the circuit manifest several forms of synaptic plasticity. Here, we developed a model of the circuit and investigated the ways in which depression (DEP) and potentiation (POT) contributed to information processing. DEP limited the amount of motor neuron activity that could be elicited by the monosynaptic pathway alone. POT within the monosynaptic pathway did not compensate for DEP. There was, however, a synergistic interaction between POT and the polysynaptic pathway. This synergism extended the dynamic range of the network, and the interplay between DEP and POT made the circuit respond preferentially to long-duration, low-frequency inputs. Model Neurons More Cells Aplysia motor neuron   show other Aplysia interneuron   show other Aplysia sensory neuron   show other Model Currents I K   show other I N   show other I Potassium   show other I Sodium   show other Model Receptors AMPA   show other Model Type Network   show other Model Concept Synaptic Plasticity   show other Synchronization   show other Action Potentials   show other Depression   show other Facilitation   show other Post-Tetanic Potentiation   show other Sensory processing   show other Short-term Synaptic Plasticity   show other Model papers Baxter DA, Byrne JH (2007)   show other Simulator software SNNAP   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Aplysia   show other Model ID Number Gap Junctions Implemented by Baxter, Douglas   show other Read write access code Public Submitter Email Address douglas.baxter@uth.tmc.edu Model Neurotransmitters Glutamate   show other Other Neuron Aplysia Sensory Neuron Other Receptor Other Current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Alternative Version Citation Baxter DA Byrne JH (2006) Short-term plasticity in a computational model of the tail-withdrawal circuit in Aplysia, Neurocomputing, doi:10.1016/j.neurcom.2006.10.080 Default File Notes Other Gene Simulation Platform ID Has Model View 0 Other categories referring to "Homosynaptic plasticity in the tail withdrawal circuit (TWC) of Aplysia (Baxter and Byrne 2006)"   Revisions: 12 Last time: 8/19/2011 10:02:25 AM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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