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SenseLab  Home Data Search Schema Login	[Data] Computational model Name The role of ATP-sensitive potassium channels in a hippocampal neuron (Huang et al. 2007) Model File Neuron_KATP [? bytes] Notes "Hyperglycemia-related neuronal excitability and epileptic seizures are not uncommon in clinical practice. However, their underlying mechanism remains elusive. ATP-sensitive K(+) (K(ATP)) channels are found in many excitable cells, including cardiac myocytes, pancreatic beta cells, and neurons. These channels provide a link between the electrical activity of cell membranes and cellular metabolism. We investigated the effects of higher extracellular glucose on hippocampal K(ATP) channel activities and neuronal excitability. The cell-attached patch-clamp configuration on cultured hippocampal cells and a novel multielectrode recording system on hippocampal slices were employed. In addition, a simulation modeling hippocampal CA3 pyramidal neurons (Pinsky-Rinzel model) was analyzed to investigate the role of K(ATP) channels in the firing of simulated action potentials. ..." Model Neurons CA3 pyramidal neuron   show other More Cells Model Currents I Potassium   show other I K   show other ATP-senstive potassium current   show other Model Receptors Model Type Neuron or other electrically excitable cell   show other Model Concept Oscillations   show other Epilepsy   show other Activity Patterns   show other Action Potentials   show other Bursting   show other Model papers Huang CW, Huang CC, Cheng JT, Tsai JJ, Wu SN (2007)   show other Simulator software XPP   show other Gene hg folder name (applicable when in ModelDB hg) Region Organism Model ID Number Gap Junctions Implemented by Huang, Chin-Wei   show other Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]   show other Read write access code Public Submitter Email Address snwu@mail.ncku.edu.tw Model Neurotransmitters Other Neuron Other Receptor Other Current ATP-senstive potassiun current Other Neurotransmitter Other Model Type Other Concept Other Simulator Other Implementer Dr. Chin-Wei Huang Alternative Version Citation 17410601 Default File Notes Other Gene Simulation Platform ID Has Model View 0 Other categories referring to "The role of ATP-sensitive potassium channels in a hippocampal neuron (Huang et al. 2007)"   Revisions: 5 Last time: 4/13/2007 8:06:40 AM Reviewer: Tom Morse - MoldelDB admin Owner: Tom Morse - MoldelDB admin
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