Pathological mechanism having Alzheimer as Pathology

Name/Notes 1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.      2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation      3 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice      4 Abeta decreases dedritic spine number and alters dendritic spine morpholology      5 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e      6 Abeta decreases dendritic spine number, causes dysmorphic spine shapes      7 Abeta inhibits late LTP in animal models of Alzheimers      8 Abeta inhibits LTP both in soluble and fibrillar conformational states      9 Abeta inhibits LTP through TNFalpha      10 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals       11 Abeta modulates A current (HEK293 cells)      12 Abeta peptides block LTP in rat CA1 in vivo      13 Abeta-derived diffusible ligands (ADDLs) attack synapses at or near NMDA receptors      14 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers      15 Alpha4beta2 receptor blockade causes memory impairment      16 AMPA receptor downscaling in AD      17 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density      18 BACE1 required for LTP at mossy fiber-CA3 synapses      19 beta Amyloid increases calcium currents (2)      20 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP      21 beta-Amyloid impairs LTP/LTD      22 beta-amyloid reduces IA      23 beta-Amyloid-induced depression of LTP attenuated by Verapamil      24 Chronic nicotine decreases NGF and improves memory performance      25 Donepezil modulates potassium channels      26 Drebrin decrease in frontal cortex correlated with mild Alzheimer's disease      27 Galantamine increases dopamine release in the hippocampus      28 Histidine associating compounds block Abeta Channel activity and cytotoxicity      29 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice      30 LTP requires BDNF and is associated with cytoskeleton-associated protein      31 Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist      32 Model block of I_A      33 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla      34 Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline      35 Nicotine desensitize alpha7 nACh receptors and facilitates LTP      36 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo      37 Okadaic acid mediates tau phosphorylation via L channel activation      38 p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro      39 Picomolar concentrations of abeta monomers disrupt LTP      40 Presenilin-1 deficient neurons have increased activity of L channels      41 Protofibrillar intermediates of ABeta change firing pattern of neurons.      42 Regulation of back-propagating action potentials in hippocampal neurons.      43 Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice      44 Synaptic integration is disrupted in an AD mouse model      45 The channel hypothesis of Alzheimers disease