Pathological mechanism having Blocks as Pharmacological Action

Name/Notes 1 Abeta (1-42) increases dopamine release in the prefrontal cortex      2 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e      3 Abeta decreases dendritic spine number, causes dysmorphic spine shapes      4 Abeta increase in A-type K+ current is caused by modulation of Kv4 subunit expression      5 beta Amyloid increases calcium currents (2)      6 beta-Amyloid-induced depression of LTP attenuated by Verapamil      7 Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.      8 Histidine associating compounds block Abeta Channel activity and cytotoxicity      9 p35/Cdk5 pathway mediates soluble amyloid-beta peptide-induced tau phosphorylation in vitro