Pathological mechanism having Hippocampus as Brain region

Name/Notes 1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.      2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation      3 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e      4 Abeta inhibits late LTP in animal models of Alzheimers      5 Abeta inhibits LTP both in soluble and fibrillar conformational states      6 Abeta inhibits LTP through TNFalpha      7 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals       8 Abeta peptides block LTP in rat CA1 in vivo      9 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers      10 Alpha4beta2 receptor blockade causes memory impairment      11 AMPA receptor downscaling in AD      12 Apolipoprotein E4 (Apo E4) levels are inversely correlated with dendritic spine density      13 BACE1 required for LTP at mossy fiber-CA3 synapses      14 beta Amyloid increases calcium currents (2)      15 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP      16 beta-Amyloid impairs LTP/LTD      17 beta-amyloid reduces IA      18 beta-Amyloid-induced depression of LTP attenuated by Verapamil      19 Galantamine increases dopamine release in the hippocampus      20 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice      21 LTP requires BDNF and is associated with cytoskeleton-associated protein      22 Model block of I_A      23 Neurofibrillary tangles are correlated with spinophilin and with Alzheimer's cognitive decline      24 Nicotine desensitize alpha7 nACh receptors and facilitates LTP      25 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo      26 Regulation of back-propagating action potentials in hippocampal neurons.