Pathological mechanism having β-Amyloid as Extracelular pathological element

Name/Notes 1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.      2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation      3 Abeta decreases apical dendrite arborizations in cortical pyramidal cells in transgenic mice      4 Abeta decreases dedritic spine number and alters dendritic spine morpholology      5 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e      6 Abeta decreases dendritic spine number, causes dysmorphic spine shapes      7 Abeta inhibits late LTP in animal models of Alzheimers      8 Abeta inhibits LTP both in soluble and fibrillar conformational states      9 Abeta inhibits LTP through TNFalpha      10 Abeta inhibits nicotinic ACh receptors at pre-synaptic glutamatergic terminals       11 Abeta modulates A current (HEK293 cells)      12 Abeta peptides block LTP in rat CA1 in vivo      13 Abeta42/Abeta40 ratio correlates with impaired LTP in a mouse model of Alzheimers      14 AMPA receptor downscaling in AD      15 beta Amyloid increases calcium currents (2)      16 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP      17 beta-Amyloid impairs LTP/LTD      18 beta-amyloid reduces IA      19 beta-Amyloid-induced depression of LTP attenuated by Verapamil      20 Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.      21 Histidine associating compounds block Abeta Channel activity and cytotoxicity      22 Large decrease in spines in plaque-free regions of dentate gyrus in APP/PS1 mice      23 Memory loss caused by beta-amyloid protein is rescued by a beta(3)-adrenoceptor agonist      24 Model block of I_A      25 Muscarinic receptor agonists and nicotine may prevent neurodegeneration in AD      26 Neurocortical synapse density decrease correlates with cognitive decline much more strongly than pla      27 Nicotine enhances depressive actions of Abeta on LTP in rat CA1 region in vivo      28 Picomolar concentrations of abeta monomers disrupt LTP      29 Sub-nanomolar concentrations of oligomeric beta amyloid inhibits late LTP in rats and mice      30 The channel hypothesis of Alzheimers disease