Claims List

Name/ 1 A-type K+ channel block causes increased back-propagation of action potentials  2 A-type K+ channel block makes dendrites more excitable  3 Aß causes increased Ca++ influx by activation of L-type Ca++ channels   4 Aß influences neuronal excitability by effects on dendritic ion channels  5 Back-propagating action potentials influence LTP and LTD  6 Blockage of the hyperpolarizing A-type K+ channels makes the dendrites more excitable  7 Increased excitability can increase Ca++ influx causing synaptic effects and excitotoxicity  8 Loss/alteration of dendritic spines in early Alzheimer's  9 Pathological plaques and tangles in Alzheimer's are primarily in and around dendrites  10 Shepherd Dendritic Hypothesis  11 Soluble Aß affects CA1 Hippocampal neurons by action on A-type channels