Pathological mechanism having Brain slice preparations as Cell model

Name/Notes 1 Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.      2 Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation      3 Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e      4 Abeta inhibits LTP through TNFalpha      5 Alpha4beta2 receptor blockade causes memory impairment      6 Amyloid plaques increase elimination of dendritic spines      7 BACE1 required for LTP at mossy fiber-CA3 synapses      8 Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP      9 Galantamine increases dopamine release in the hippocampus      10 Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.      11 Nicotine desensitize alpha7 nACh receptors and facilitates LTP