: Brain Pharmacology Database
Brain slice preparations
Abeta antagonizes alpha7 nAChR receptors; opposed by nicotine.
Abeta blocks voltage-gated Na+ channels in GABA neurons causing abberant excitation
Abeta decreases dendritic spine density and motility, increases spine legth. Rolipram blocks these e
Abeta inhibits LTP through TNFalpha
Alpha4beta2 receptor blockade causes memory impairment
Amyloid plaques increase elimination of dendritic spines
BACE1 required for LTP at mossy fiber-CA3 synapses
Beta-amyloid blocks high frequency stimulation induced LTP but not nicotine enhanced LTP
Galantamine increases dopamine release in the hippocampus
Glutamatergic synaptic depression by synthetic amyloid beta-peptide in the medial septum.
Nicotine desensitize alpha7 nACh receptors and facilitates LTP
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