ModelDB: Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)

Ionic basis of alternans and Timothy Syndrome (Fox et al. 2002), (Zhu and Clancy 2007)

Accession: 104623

From Zhu and Clancy: "... Here we employ theoretical simulations to examine the effects of a Timothy Syndrome (TS) mutation in the L-type Ca2+ channel on cardiac dynamics over multiple scales, from a gene mutation to protein, cell, tissue, and finally the ECG, to connect a defective Ca2+ channel to arrhythmia susceptibility. ..."
References:
1. Fox JJ, McHarg JL, Gilmour RF (2002) Ionic mechanism of electrical alternans. Am J Physiol Heart Circ Physiol 282:H516-30 [PubMed]
2. Zhu ZI, Clancy CE (2007) L-type Ca2+ channel mutations and T-wave alternans: a model study. Am J Physiol Heart Circ Physiol 293:H3480-9 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):	I Na,t; I L high threshold; I Calcium; I Potassium; Na/Ca exchanger; I_Ks; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	C or C++ program;
Model Concept(s):	Temporal Pattern Generation; Heart disease; Long-QT; Timothy Syndrome; Sodium pump;
Implementer(s):	Zhu, Zheng I. [zhz2001 at med.cornell.edu];

Search NeuronDB for information about: I Na,t; I L high threshold; I Calcium; I Potassium; Na/Ca exchanger; I_Ks; Na/K pump;

Model files

Help downloading and running models

TS_mutation

readme.html

screenshot.jpg

cellular_model_TS_mutation.cpp

This is the readme for the model associated with

J. J. Fox, J. L. McHarg, and R. F. Gilmour Jr,
Ionic mechanism of electrical alternans,
Am J Physiol Heart Circ Physiol 2002; 282: 516-530

and

Zheng I. Zhu and Colleen E. Clancy
Am J Physiol Heart Circ Physiol. published 12 October 2007,
10.1152/ajpheart.00476.2007

Usage:

The code author, Zheng Zhu, recreated the Fox et al. model in a C++
program which conforms to ansi so it can be built with gnu C++.  For
example under linux , compile with
 
g++ cellular_model_TS_mutation.cpp -lm -O4 -o ts

and then run with

./ts

(enter a file name like a.dat when asked)

The program iterates 100 times and finishes within a minute or so.
You can produce graphs after starting octave, for example, with
commands like

load a.dat
plot (a(:,1),a(:,3))

(graphs the voltage trajectory:)

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