ModelDB: Tonic-clonic transitions in a seizure simulation (Lytton and Omurtag 2007)

Tonic-clonic transitions in a seizure simulation (Lytton and Omurtag 2007)

Accession: 105507

"... The authors have ... computationally manageable networks of moderate size consisting of 1,000 to 3,000 neurons with multiple intrinsic and synaptic properties. Experiments on these simulations demonstrated the presence of epileptiform behavior in the form of repetitive high-intensity population events (clonic behavior) or latch-up with near maximal activity (tonic behavior). ... Several simulations revealed the importance of random coincident inputs to shift a network from a low-activation to a high-activation epileptiform state. Finally, a simulated anticonvulsant acting on excitability tended to preferentially decrease tonic activity."
Reference: Lytton WW, Omurtag A (2007) Tonic-clonic transitions in computer simulation. J Clin Neurophysiol 24:175-81 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Epilepsy;
Implementer(s):	Lytton, William [billl at neurosim.downstate.edu];

Model files

Help downloading and running models Versions

This is the readme for the model for

Lytton WW; Omurtag A. Tonic-clonic transitions in computer
simulation.  J Clinical Neurophys, 24:175-181, 2007.
PMID: 17414973

Usage Notes:

To recreate Fig. 4: (will likely only run under unix); after
installing a version at least as recent as NEURON -- Release 6.1.1
(1894) 2007-11-24 (version displayed when you start nrngui) type the
following:

nrnivmodl
nrngui batch_.hoc

In under 2 minutes (on 2.8GHz Pentium 4) a display shows Expressor
Field at top (black) Expressor (blue) and Driver (red) rasters 2
Expressor voltage traces at bottom y-axis is arbitrary except for
rasters:



This version recreates the connectivity matrix with different seeds
and is therefore not identical to the original (I was not being
careful with seeds at the time since I was storing the connectivity)

in addition to the graph, a panel is launched that allows you to look
at several other voltage traces that were recorded during the run

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