| Ionic mechanisms of bursting in CA3 pyramidal neurons (Xu and Clancy 2008) |
| Accession: 114337 |
"... We present a single-compartment model of a CA3 hippocampal pyramidal neuron based on recent experimental data. We then use the model to determine the roles of primary depolarizing currents in burst generation.
The single compartment
model incorporates accurate representations of sodium (Na+) channels (NaV1.1) and T-type calcium (Ca2+) channel subtypes
(CaV3.1, CaV3.2, and CaV3.3).
Our simulations predict the importance of Na+ and T-type Ca2+ channels in hippocampal
pyramidal cell bursting and reveal the distinct contribution of each subtype to burst morphology.
We also performed fastslow
analysis in a reduced comparable model, which shows that our model burst is generated as a result of the interaction
of two slow variables, the T-type Ca2+ channel activation gate and the Ca2+-dependent potassium (K+) channel activation
gate.
The model reproduces a range of experimentally observed phenomena including afterdepolarizing potentials, spike widening at the end of the burst, and rebound.
Finally, we use the model to simulate the effects of two epilepsy-linked
mutations: R1648H in NaV1.1 and C456S in CaV3.2, both of which result in increased cellular excitability."
Reference: Xu J, Clancy CE (2008) Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. PLoS ONE 3:e2056 [PubMed] |
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This is the readme for the model associated with the publication
Xu J, Clancy CE. Ionic mechanisms of endogenous bursting in CA3
hippocampal pyramidal neurons: a model study. PLoS ONE. 2008 Apr
30;3(4):e2056.
Usage:
(linux/unix) After extracting the archive compile the model with a
command like
g++ ca3_single_compartment.cpp -o run
Then run the file with a command like
./run > output.dat
After completion output.dat contains the data that produced the bottom
trace in figure 1 C.
This data is also available in the first two columns of a file,
out_one, that was produced during the run. The other columns contain
ionic currents as shown in figure 4.
These model files were submitted by Dr Colleen Clancy.
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