| Activity dependent changes in dendritic spine density and spine structure (Crook et al. 2007) |
| Accession: 114342 |
"... In this work, we extend previous modeling studies [27] by combining a model for activity-dependent spine density with one for
calcium-mediated spine stem restructuring.
... Additional equations characterize the change in spine density along
the dendrite, the current balance equation for an individual spine
head, the change in calcium concentration in the spine head, and the
dynamics of spine stem resistance.
We use computational studies to investigate the changes in spine
density and structure for differing synaptic inputs and demonstrate
the effects of these changes on the input-output properties of the
dendritic branch.
... "
Reference: Crook SM, Dur-E-Ahmad M, Baer SM (2007) A model of activity-dependent changes in dendritic spine density and spine structure. Math Biosci Eng 4:617-31 [PubMed] |
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This is the readme for the model associated with paper
Crook SM, Dur-E-Ahmad M, Baer SM (2007) A model of activity-dependent
changes in dendritic spine density and spine structure. Math Biosci
Eng 4:617-31
These matlab files were supplied by Dr Sharon Crook.
Usage:
After extracting the archive start matlab and cd to the mbe folder
created by expanding the archive Run with the command
run run_sp
After finishing (7 minutes on a 3 GHz 2007 Pentium 4) the program
reproduces figure 8 from the paper, for example the spine head voltage:
and the Ca concentration:
A figure8 data file is also created that stores these traces.
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