ModelDB: Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)

Axonal NaV1.6 Sodium Channels in AP Initiation of CA1 Pyramidal Neurons (Royeck et al. 2008)

Accession: 115356

"... We show that the Na+ channel NaV1.6 displays a striking aggregation at the AIS of cortical neurons. ... In combination with simulations using a realistic computer model of a CA1 pyramidal cell, our results imply that a hyperpolarized voltage-dependence of activation of AIS NaV1.6 channels is important both in determining spike threshold and localizing spike initiation to the AIS. ... These results suggest that NaV1.6 subunits at the AIS contribute significantly to its role as spike trigger zone and shape repetitive discharge properties of CA1 neurons."
Reference: Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role of Axonal NaV1.6 Sodium Channels in Action Potential Initiation of CA1 Pyramidal Neurons. J Neurophysiol [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I M; I h; I K,Ca; I Calcium; I Q;
Gap Junctions:
Receptor(s):
Gene(s):	Nav1.6 SCN8A;
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Ion Channel Kinetics; Temporal Pattern Generation;
Implementer(s):	Horstmann, Marie-Therese [mhorstma at uni-bonn.de];

Search NeuronDB for information about: CA1 pyramidal neuron; I Na,p; I Na,t; I L high threshold; I N; I T low threshold; I p,q; I A; I K; I M; I h; I K,Ca; I Calcium; I Q;

Model files

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This is the readme for the model associated with the paper:

Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H (2008) Role
of Axonal NaV1.6 Sodium Channels in Action Potential Initiation of CA1
Pyramidal Neurons.

These model files were supplied by Dr Marie-Therese Horstmann.

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