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CA1 pyramidal neuron synaptic integration (Jarsky et al. 2005)
Accession: 116084
"The perforant-path projection to the hippocampus forms synapses in the apical tuft of CA1 pyramidal neurons. We used computer modeling to examine the function of these distal synaptic inputs, which led to three predictions that we confirmed in experiments using rat hippocampal slices. ... This 'gating' of dendritic spike propagation may be an important activation mode of CA1 pyramidal neurons, and its modulation by neurotransmitters or long-term, activity-dependent plasticity may be an important feature of dendritic integration during mnemonic processing in the hippocampus."
Reference: Jarsky T, Roxin A, Kath WL, Spruston N (2005) Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nat Neurosci 8:1667-76 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):  CA1 pyramidal neuron;  
Channel(s):   
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  Neuron (web link to model);
Model Concept(s):  Influence of Dendritic Geometry; Detailed Neuronal Models; Synaptic Integration;
Implementer(s):  
Search NeuronDB for information about:  CA1 pyramidal neuron;
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Spruston / Kath main

Note from the ModelDB Administrator: the below links copied September 2012 from the Spruston/Kath link http://dendrites.esam.northwestern.edu/NN_2005/gating.htm. Nelson Spruston is now at Janelia Farm: http://www.janelia.org/people/administration/nelson-spruston

"Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons"

Tim Jarsky, Alex Roxin, William L. Kath, and Nelson Spruston

Nature Neuroscience, 2005

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