ModelDB: CA1 pyramidal neuron: h channel-dependent deficit of theta oscill. resonance (Marcelin et al. 2008)

CA1 pyramidal neuron: h channel-dependent deficit of theta oscill. resonance (Marcelin et al. 2008)

Accession: 116983

This model was used to confirm and support experimental data suggesting that the neuronal/circuitry changes associated with temporal lobe epilepsy, including Ih-dependent inductive mechanisms, can disrupt hippocampal theta function.
Reference: Marcelin B, Chauviere L, Becker A, Migliore M, Esclapez M, Bernard C (2009) h channel-dependent deficit of theta oscillation resonance and phase shift in temporal lobe epilepsy. Neurobiol Dis 33(3):436-447 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	CA1 pyramidal neuron;
Channel(s):	I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Oscillations; Detailed Neuronal Models; Epilepsy;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];

Search NeuronDB for information about: CA1 pyramidal neuron; I h;

Model files

Help downloading and running models

ondelette-No-Gain-1-4Hz.txt

NEURON mod files from the paper:

Marcelin B, Chauvière L, Becker A, Migliore M, Esclapez M, Bernard C.
h channel-dependent deficit of theta oscillation resonance and phase shift 
in temporal lobe epilepsy,
Neurobiol Dis. 2008 Dec 16. [Epub ahead of print]

In the paper, this model was used to confirm and support experimental data
suggesting that the neuronal/circuitry changes associated with temporal lobe epilepsy,
including Ih-dependent inductive mechanisms, can disrupt hippocampal theta function.

The simulation theta.hoc reproduces the upper left trace in Fig.5A of the paper.

Be aware that the simulation is rather long (several hours).

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui theta.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
theta.hoc 
will open the simulation window.

Under MAC OS X:
Drag and drop the extracted theta folder to the mknrndll icon.
Drag and drop the mosinit.hoc file to the nrngui icon

michele.migliore@pa.ibf.cnr.it

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