| Competition for AP initiation sites in a circuit controlling simple learning (Cruz et al. 2007) |
| Accession: 117459 |
"The spatial and temporal patterns of action potential initiations were studied in a behaving leech preparation to determine the basis of increased firing that accompanies sensitization, a form of non-associative learning requiring the
S-interneurons.
...
The S-interneurons, one in each ganglion and linked by electrical synapses with both neighbors to form a chain, are interposed between sensory
and motor neurons.
...
the single site with the largest initiation rate, the S-cell in the
stimulated segment, suppressed initiations in adjacent ganglia.
Experiments showed this was both because (1) it received the earliest, greatest input and (2) the delayed synaptic
input to the adjacent S-cells coincided with the action potential refractory period.
A compartmental model of the S-cell and its inputs showed that a simple, intrinsic mechanism of inexcitability after each action potential may account for suppression of impulse initiations.
Thus, a non-synaptic competition between neurons alters synaptic integration in the chain.
In one mode, inputs to different sites sum independently, whereas in another, synaptic input to a single site precisely specifies the overall pattern of activity."
Reference: Cruz GE, Sahley CL, Muller KJ (2007) Neuronal competition for action potential initiation sites in a circuit controlling simple learning. Neuroscience 148:65-81 [PubMed] |
| Citations Citation Browser
|
Model Information (Click on a link to
find other models with that property)
|
| Search NeuronDB for information about: I Na,t; I K,leak; Serotonin; |
|
|
|
| This is the readme for the model associated with the paper:
Cruz GE, Sahley CL, Muller KJ (2007) Neuronal competition for action
potential initiation sites in a circuit controlling simple
learning. Neuroscience 148:65-81
Each model in a folder corresponds to an experiment in the paper,
particularly relative refractory periods with and without 5-HT. The
2-cell model emulates the electrophysiology and the 3-cell model is a
"biological" representation including synaptic input.
These model files were supplied by Dr Ginny Cruz.
| |
