| Experimental and modeling studies of desensitization of P2X3 receptors (Sokolova et al. 2006) |
| Accession: 117691 |
"The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood.
The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic
modeling to clarify the properties of P2X3 receptor desensitization.
...
Desensitization properties were well accounted for by a cyclic model in which
receptors could be desensitized from either open or closed
states.
Recovery was assumed to be a multistate process with distinct kinetics dependent on the agonist-dependent dissociation rate from desensitized receptors.
...
By using subthreshold concentrations of an HAD (high-affinity desensitization)-potent agonist, it might be possible
to generate sustained inhibition of P2X3 receptors for controlling
chronic pain."
Reference: Sokolova E, Skorinkin A, Moiseev I, Agrachev A, Nistri A, Giniatullin R (2006) Experimental and modeling studies of desensitization of P2X3 receptors. Mol Pharmacol 70:373-82 [PubMed] |
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| This is the readme for the model associated with the paper:
Sokolova E, Skorinkin A, Moiseev I, Agrachev A, Nistri A, Giniatullin R (2006)
Experimental and modeling studies of desensitization of P2X3 receptors.
Mol Pharmacol 70:373-82
These model files were supplied by Dr Andrei Skorinkin.
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These model files require Delphi 6 or greater. Start with the file
DS_especial.dpr
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