ModelDB: Calyx of Held, short term plasticity (Yang Z et al. 2009)

Calyx of Held, short term plasticity (Yang Z et al. 2009)

Accession: 118554

This model investigates mechanisms contributing to short term plasticity at the calyx of Held, a giant glutamatergic synapse in the mammalian brainstem auditory system. It is a stochastic version of the model described in: Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2007). A biophysical model of short-term plasticity at the calyx of Held. Neurocomputing, 70:1626-1629. This version introduces stochastic vesicle recycling and release. It has been used to investigate the information transmission properties of this synapse, as detailed in: Yang, Z., Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2008). Wide-band information transmission at the calyx of Held. Neural Computation, 21(4):991-1018.
References:
1. Yang Z, Hennig MH, Postlethwaite M, Forsythe ID, Graham BP (2009) Wide-band information transmission at the calyx of held. Neural Comput 21:991-1017 [PubMed]
2. Hennig MH, Postlethwaite M, Forsythe ID, Graham BP (2007) A biophysical model of short-term plasticity at the calyx of Held, Neurocomputing 70(12):1626-1629

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Synapse;
Brain Region(s)/Organism:	Auditory brainstem;
Cell Type(s):	Medial Nucleus of the Trapezoid Body (MNTB) neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Glutamate;
Simulation Environment:	MATLAB;
Model Concept(s):	Short-term Synaptic Plasticity;
Implementer(s):	Hennig, Matthias H [mhhennig at gmail.com];

Search NeuronDB for information about: Glutamate;

Model files

Help downloading and running models

Public release 30-11-08

Stochastic model of STP at the Calyx of Held
--------------------------------------------

This model investigates mechanisms contributing to short term
plasticity at the calyx of Held, a giant glutamatergic synapse
in the mammalian brainstem auditory system. It is a stochastic
version of the model described in:
 
Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2007). 
A biophysical model of short-term plasticity at the calyx of Held. 
Neurocomputing, 70:1626-1629.

This version introduces stochastic vesicle recycling and release.
It has been used to investigate the information transmission
properties of this synapse, as detailed in:

Yang, Z., Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2008). 
Wide-band information transmission at the calyx of Held. 
Neural Computation, 21(4):991-1018.

The model is written in Matlab. The provided main file runs the
model for 1 second of simulated time with stimulation by regular
frequencies of 10, 20, 50 and 100Hz, for comparison with
experimental data from the calyx.  A graph similar to Figure 1 from
the paper is created:



Main file: run_model.m

Model file: coh_stoch_mod.m

Stimulation file: inhreg.m

Experimental data in expdata folder.

These model files supplied by Bruce Graham.

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