ModelDB: Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)

Effects of KIR current inactivation in NAc Medium Spiny Neurons (Steephen and Manchanda 2009)

Accession: 121060

"Inward rectifying potassium (KIR) currents in medium spiny (MS) neurons of nucleus accumbens inactivate significantly in ~40% of the neurons but not in the rest, which may lead to differences in input processing by these two groups. Using a 189-compartment computational model of the MS neuron, we investigate the influence of this property using injected current as well as spatiotemporally distributed synaptic inputs. Our study demonstrates that KIR current inactivation facilitates depolarization, firing frequency and firing onset in these neurons. ..."
Reference: Steephen JE, Manchanda R (2009) Differences in biophysical properties of nucleus accumbens medium spiny neurons emerging from inactivation of inward rectifying potassium currents. J Comput Neurosci [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:	Basal ganglia;
Cell Type(s):	Nucleus accumbens medium spiny projection neuron;
Channel(s):	I Na,p; I L high threshold; I T low threshold; I p,q; I A; I h; I K,Ca; I CAN; I A, slow; I Krp; I R;
Gap Junctions:
Receptor(s):	AMPA; NMDA; Gaba;
Gene(s):	Cav1.3 CACNA1D; Cav1.2 CACNA1C; IRK;
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Ion Channel Kinetics; Action Potentials; Synaptic Integration; Delay;
Implementer(s):	Steephen, John Eric [johneric at iitb.ac.in];

Search NeuronDB for information about: AMPA; NMDA; Gaba; I Na,p; I L high threshold; I T low threshold; I p,q; I A; I h; I K,Ca; I CAN; I A, slow; I Krp; I R;

Model files

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Reproduces all simulations from:

Steephen, J. E., & Manchanda, R. (2009). Differences in biophysical
properties of nucleus accumbens medium spiny neurons emerging from
inactivation of inward rectifying potassium currents.
J Comput Neurosci
doi:10.1007/s10827-009-0161-7

This implementation by John Eric Steephen (johneric@iitb.ac.in) to
whom questions should be addressed.

Usage: Auto-launch from ModelDB and skip to step 4 or
1. Unzip MSN2009.zip into an empty directory.
2. Compile the mod files with mknrndll (or nrnivmodl in unix).
3. Double click on main.hoc (or drag and drop onto nrngui (MAC), or
   start with "nrngui main.hoc" (unix/linux)).
4. A window with the title Control Panel will appear with several
   controls, one of which will be the "Help" button. Click the
   "Help" button to see instructions on how to reproduce the
   simulations described in the paper.

Example:
After right clicking on the graph and selecting "Keep lines" follow the
instructions in the "Help" panel to recreate figure 1B from the paper:



20111102 Files chan_Cadyn.mod chan_CaN.mod updated to use
derivimplicit.  See
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592 for more.
20120201 chan_CaKdyn.mod chan_CaL12.mod chan_CaL13.mod chan_CaQ.mod
chan_CaR.mod chan_CaT.mod also updated to not use euler (see above
link to neuron forum).

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