| Submyelin Potassium accumulation in Subthalamic neuron (STN) axons (Bellinger et al. 2008) |
| Accession: 121253 |
"To better understand the direct effects of DBS (Deep brain stimulation) on central neurons, a computational model of a myelinated axon has been constructed which includes the effects of K+ accumulation within the peri-axonal space.
Using best estimates of anatomic and electrogenic model parameters for in vivo STN axons, the model predicts a functional block along the axon due to K+ accumulation in the submyelin space.
...
These results suggest that therapeutic DBS of the STN likely results in a functional block for many STN axons, although a subset of STN axons may also be activated at the stimulating frequency.
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Reference: Bellinger SC, Miyazawa G, Steinmetz PN (2008) Submyelin potassium accumulation may functionally block subsets of local axons during deep brain stimulation: a modeling study. J Neural Eng 5:263-74 [PubMed] |
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This is the readme for the model associated with the paper
Bellinger SC, Miyazawa G, Steinmetz PN (2008) Submyelin potassium
accumulation may functionally block subsets of local axons during deep
brain stimulation: a modeling study. J Neural Eng 5:263-74
These model files were implemented by Bellinger and contributed to
ModelDB by Steinmetz.
Usage:
Simply auto-launch from ModelDB or download and extract the archive
then under:
mswin
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Compile the mod files with mknrndll. Double click the mosinit.hoc file
Linux
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Compile the mod files with nrnivmodl. Start by typing "nrngui mosinit.hoc"
MAC OS X
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Drag and drop the newly expanded folder onto the mknrndll icon. Drag
and drop the mosinit.hoc file within this folder onto the nrngui icon.
Once the simulation is started
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Select either the long run (1 3/4 hours on a 2.8GHz Pentium 4) or the
short run by pressing the appropriate button. The long run should
reproduce fig2b:
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