This is the readme for the NEURON model from the paper:
Ferrante et al, Feed-forward inhibition as a buffer of the neuronal
input-output relation. Proc Natl Acad Sci U S A. (2009)
In this paper, the model shows that feed-forward inhibition (FFI) can
change a steeply sigmoid I/O curve into a double-sigmoid typical of
buffer systems. Specifically Fig_1B_left.hoc and Fig_1B_left.hoc
respectively produce plots of firing response of the model MOPP cell
(left) and granule cell (right) upon somatic current injections.
Under linux/unix systems:
to compile the mod files use the command
and run the simulation hoc file with the command
Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
will open the simulation window.
Under MAC OS X:
to compile the mod files drag and drop the extracted folder onto the
mknrndll icon. Drag and drop the mosinit.hoc file onto the nrngui
Once NEURON started you can set a current amplitude in the graph
textbox, press the button "init & run" and check the corresponding
output firing rate (Hz).
When the simulations for the two cells are done the results should
look similar to these:
You can try another current amplitude and reiterate the process to
build an I-f curve (see paper for details).
Questions on how to use this model should be directed to
ModelDB Home SenseLab Home Help Questions, comments, problems? Email the ModelDB AdministratorHow to cite ModelDB This site is Copyright 2012 Shepherd Lab, Yale University