ModelDB: Availability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003)

Availability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003)

Accession: 125378

"... we measured T-type current of isolated goldfish retinal ganglion cells with perforated-patch voltageclamp methods in solutions containing a normal extracellular Ca2+ concentration. The voltage sensitivities and rates of current activation, inactivation, deactivation, and recovery from inactivation were similar to those of expressed +1G (CaV3.1) Ca2+ channel clones, except that the rate of deactivation was significantly faster. We reproduced the amplitude and kinetics of measured T currents with a numerical simulation based on a kinetic model developed for an +1G Ca2+ channel. Finally, we show that this model predicts the increase of T-type current made available between resting potential and spike threshold by repetitive hyperpolarizations presented at rates that are within the bandwidth of signals processed in situ by these neurons."
Reference: Lee SC, Hayashida Y, Ishida AT (2003) Availability of Low-Threshold Ca2+ Current in Retinal Ganglion Cells J Neurophysiol 90:3888-3901 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Channel;
Brain Region(s)/Organism:	Retina;
Cell Type(s):	Retinal ganglion cell;
Channel(s):	I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s):	Cav3.1 CACNA1G;
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Ion Channel Kinetics;
Implementer(s):	Hayashida, Yuki [yukih at cs.kumamoto-u.ac.jp];

Search NeuronDB for information about: Retinal ganglion cell; I T low threshold;

Model files

Help downloading and running models

This is the readme for the model associated with the paper:

Lee SC, Hayashida Y, Ishida AT (2003) Availability of Low-Threshold
Ca2+ Current in Retinal Ganglion Cells J Neurophysiol 90:3888-3901

The T-type Ca2+ channel mod file written by Yuki Hayashida (a modified
version of the T channel from Serrano et al. 1999) was supplied by Dr
Ishida.

Usage:

Auto-launch from ModelDB and click the start button to generate Figure
8B from the paper.  Or download and extract the archive and then under

Linux:
------
compile the mod files with nrnivmodl and then type "nrngui
mosinit.hoc"

Mac OS X:
---------
drag and drop the extracted folder onto the mknrndll icon and then
drag and drop the mosinit.hoc file onto the nrngui icon

mswin
-----
run mknrndll, traverse to the extracted folder and click to make the
nrnmech.dll.  In windows explorer traverse to the extracted folder and
double click the mosinit.hoc file.

Once the simulation is started press the start button.  In any case
you should see a figure that looks like:

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