ModelDB: Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)

Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)

Accession: 12631

Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference: Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:	Thalamus;
Cell Type(s):	Thalamic relay neuron; Thalamic reticular neuron;
Channel(s):	I Na,t; I T low threshold; I K; I CAN;
Gap Junctions:
Receptor(s):	GabaA; Gaba;
Gene(s):
Transmitter(s):	Gaba;
Simulation Environment:	Neuron;
Model Concept(s):	Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics;
Implementer(s):	Lytton, William [billl at neurosim.downstate.edu];

Search NeuronDB for information about: Thalamic relay neuron; Thalamic reticular neuron; GabaA; Gaba; I Na,t; I T low threshold; I K; I CAN; Gaba;

Model files

Help downloading and running models Versions

calciumpump_destexhe.mod

Note: This model only runs under UNIX (and linux) for the
current version of neuron (5.2).  Future versions of neuron for the
mac and pc will be able to run this model.

* simulation from:
Lytton WW. Computer model of clonazepam's effect in thalamic slice. 
Neuroreport, 8:3339-3343, 1997. 
Figs. 3 (Fig3.gif; reticularis cells) and 4 (Fig4.gif; thalamocortical cells), p 3342
neurrep8:3339.pdf

This simulation is very similar to the one published in the paper
  but is not identical due to variations among randomizers using
  supposedly identical algorithms.  The original was run under Sun
  Solaris.  The example files included here were produced under
  Intel Linux.  I have chosen traces from the current runs that are
  very similar to those in the publication.  However, these specific
  traces may not look identical if a different randomizer is used.
  I also graph all 64 traces from the network so that they can all
  be looked at and compared to the figure.

* COMPILE and RUN:
  nrnivmodl
RUN: 
  $CPU/special init.hoc -

* TO JUST LOOK AT PRE-SAVED DATA
  $CPU/special disp.hoc -

to look at your newly run data later modify disp.hoc line 23 
               FROM 
showfiles("ctl.dat","czp.dat")
                TO 
showfiles("ctlnew.dat","czpnew.dat")

20110411 changed euler solve method to cnexp in IAHP_destexhe.mod
ICAN_destexhe.mod as per "Integration methods for SOLVE statements"
topic in the NEURON forum
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
-ModelDB Adminsitrator

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University