ModelDB: CA3 pyramidal neuron (Safiulina et al. 2010)

CA3 pyramidal neuron (Safiulina et al. 2010)

Accession: 126814

In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. To compare the relative strength of CA3 pyramidal cell output in relation to their MF glutamatergic or GABAergic inputs in postnatal development, a realistic model was constructed taking into account the different biophysical properties of these synapses.
Reference: Safiulina VF, Caiati MD, Sivakumaran S, Bisson G, Migliore M, Cherubini E (2010) Control of GABA release at mossy fiber-CA3 connections in the developing hippocampus Front Synaptic Neurosci

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Model Information (Click on a link to find other models with that property)

Model Type:	Synapse; Dendrite;
Brain Region(s)/Organism:	Hippocampus;
Cell Type(s):	CA3 pyramidal neuron;
Channel(s):	I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I CAN; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):	Gaba; Glutamate;
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Dendritic Action Potentials; Bursting; Temporal Pattern Generation; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Spike Frequency Adaptation;
Implementer(s):	Migliore, Michele [Michele.Migliore at Yale.edu];

Search NeuronDB for information about: CA3 pyramidal neuron; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I CAN; I Calcium; Gaba; Glutamate;

Model files

Help downloading and running models Model View

NEURON mod files from the paper:

Control of GABA release at single mossy fiber-CA3 connections in the
developing hippocampus.  Safiulina VF, Caiati MD, Sivakumaran S,
Bisson G, Migliore M and Cherubini E (2010)
Front. Syn. Neurosci. 2:1. doi:10.3389/neuro.19.001.2010

The simulation file develop.hoc reproduces the simulations shown in
Fig.7 of the paper.

Questions on how to use this model should be directed to
michele.migliore@pa.ibf.cnr.it

Example use:

Start the model by auto-launching from ModelDB or: download and
extract the archive and compile the mod files using mknrndll (windows,
mac OS X), or nrnivmodl (linux/unix) and then start by double clicking
the mosinit.hoc (windows), dragging and dropping the mosinit.hoc onto
the nrngui icon (mac OS X), or typing "nrngui mosinit.hoc"
(linux/unix).

When the simulation is started press the appropriate button to run
under particular conditions to produce graphs as in Figure 7.  To get
exactly the same traces for each panel in the figure one has to start
the simulation from the beginning every time (to seed the random
number generator).  In the below only the first figure was started
from the beginning and therefore matches the paper while the others
are similar:

Glutamate at 20 Hertz:



Glutamate at 40 Hertz:



GABA at 20 Hertz:



GABA at 40 Hertz:

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