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A model of the temporal pattern generator of C. elegans egg-laying behavior (Zhang et. al 2010)
Accession: 127321
"... We suggest that the HSN neuron is the executive neuron driving egg-laying events. We propose that the VC neurons act as "single egg counters" that inhibit HSN activity for short periods in response to individual egg-laying events. We further propose that the uv1 neuroendocrine cells are "cluster counters", which inhibit HSN activity for longer periods and are responsible for the time constant of the inactive phase. Together they form an integrated circuit that drives the clustered egg-laying pattern. ..."
Reference: Zhang M, Schafer WR, Breitling R (2010) A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior. BMC Syst Biol 4:81 [PubMed]
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Model Information (Click on a link to find other models with that property)
Model Type:  Network;
Brain Region(s)/Organism:  egg-laying circuit;
Cell Type(s):   HSN; VC; uv1;
Channel(s):   
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  R (web link to model);
Model Concept(s):  Temporal Pattern Generation; Simplified Models;
Implementer(s):  Breitling, Rainer; Zhang, Mi [mi.zhang at gmail.com];
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An R file (R is available from http://www.R-project.org for the model for the paper

A circuit model of the temporal pattern generator of Caenorhabditis egg-laying behavior
Zhang M, Schafer WR, Breitling R
BMC Systems Biology 2010, 4:81 (7 June 2010)

is available from this link provided in the supplemental material:
http://www.biomedcentral.com/imedia/1815250998377258/supp2.r

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