ModelDB: AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)

AP back-prop. explains threshold variability and rapid rise (McCormick et al. 2007, Yu et al. 2008)

Accession: 135839

This simple axon-soma model explained how the rapid rising phase in the somatic spike is derived from the propagated axon initiated spike, and how the somatic spike threshold variance is affected by spike propagation.
References:
1. McCormick DA, Shu Y, Yu Y (2007) Hodgkin and Huxley model still standing? Nature 445:E1-E2 [PubMed]
2. Yu Y, Shu Y, McCormick DA (2008) Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. J Neurosci 28:7260-72 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell; Axon;
Brain Region(s)/Organism:	Neocortex;
Cell Type(s):	Neocortical pyramidal neuron: deep; Neocortical pyramidal neuron: superficial;
Channel(s):	I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;
Gap Junctions:
Receptor(s):	GabaA; NMDA;
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Detailed Neuronal Models;
Implementer(s):

Search NeuronDB for information about: Neocortical pyramidal neuron: deep; Neocortical pyramidal neuron: superficial; GabaA; NMDA; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca; I_AHP;

Model files

Help downloading and running models Versions

McCormickEtAl2007YuEtAl2008

Rapid_rising_somatic_spike_soma_axon.hoc

mosinit.hoc

neuron_soma.dat

for_plot_spike.m

These model files were for the paper:

Yu Y.G., Shu Y., Duque A., Haider B., and McCormick D.A.  
Cortical Action Potential Back-propagation Explains Spike Threshold
Variability and Rapid-Onset Kinetics.
Journal of Neuroscience, 28: 7260-7272, (2008).

and also

McCormick D.A., Shu Y., and Yu Y.G.     
Neurophysiology: Hodgkin and Huxley model - still standing?
Nature. 445: E1-E2, (2007).  

This simple axon-soma model explained how the rapid rising phase in
somatic spike is derived from propagated axon initiated spike.

Creates a single cell containing a dendrite, soma, an axon with 60
micrometer and a axon bleb to investigate generation of spike kink at
soma. As observed in experiment, spikes are usually initiated at the
axon site 40~70 micrometer away from soma.  There is a rapid rising
phase in somatic spike, due to the initial segment traveling spike.

After running the code, there is an output data file called
'neuron_soma.dat' Use the matlab code for_plot_spike.m to plot the
somatic spike and axon spike.

These files were contributed by
Yuguo Yu
Yale University

yuguo.yu@yale.edu

20111026 updated release.mod to derivimplicit method.  See file for
more info.
20120409 updated cad.mod capump.mod to derivimplicit method which
should have been changed with above 20111026 update. See
http://www.neuron.yale.edu/phpBB/viewtopic.php?f=28&t=592
20120515 Ted Carnevale supplied these updates which are THREADSAFE,
slightly cleaner code, and handle singularities correctly (ca.mod,
km.mod, and kv.mod didn't).

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University