| CA1 stratum radiatum interneuron multicompartmental model (Katona et al. 2011) |
| Accession: 136176 |
The model examines dendritic NMDA-spike generation and propagation
in the dendrites of CA1 stratum radiatum interneurons. It contains
NMDA-channels in a clustered pattern on a dendrite and K-channels. The
simulation shows the whole NMDA spike and the rising phase of the
traces in separate windows.
Reference: Katona G, Kaszas A, Turi GF, Hajos N, Tamas G, Vizi ES, Rozsa B (2011) Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons. Proc Natl Acad Sci U S A 108:2148-53 [PubMed] |
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| Search NeuronDB for information about: NMDA; I Na,t; I K; |
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| This is the readme file for the NEURON simulation demonstrating NMDA spikes in interneurons
Instructions to run the model under Windows Xp or Win7:
1. Start mknrndll
2. Select as working directory the folder "Katona_et_al"
3. press the button "Make nrnmech.dll"
4. start Neuron
5. Select as working directory the folder "Katona_et_al"
6. type Enter
7. copy the following line to oc> command prompt: load_file("basal.hoc")
8. Please remove nmda synapses one by one from the PointProcessGroupManager window using the remove button
Graph[1] demonstrates NMDA spikes in a reconstructed CA1 stratum radiatum interneuron
Graph[2] shows the enlarged view of the initiation phase of the spike
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