ModelDB: Laminar analysis of excitatory circuits in vibrissal motor and sensory cortex (Hooks et al. 2011)

Laminar analysis of excitatory circuits in vibrissal motor and sensory cortex (Hooks et al. 2011)

Accession: 137743

"... We mapped local excitatory pathways in each area (primary motor cortex (vM1), primary somatosensory cortex (vS1; barrel cortex), and secondary somatosensory cortex (S2)) across all cortical layers using glutamate uncaging and laser scanning photostimulation. We analyzed these maps to derive laminar connectivity matrices describing the average strengths of pathways between individual neurons in different layers and between entire cortical layers. ..."
Reference: Hooks BM, Hires SA, Zhang YX, Huber D, Petreanu L, Svoboda K, Shepherd GM (2011) Laminar analysis of excitatory local circuits in vibrissal motor and sensory cortical areas. PLoS Biol 9:e1000572 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Network;
Brain Region(s)/Organism:
Cell Type(s):	Neocortical pyramidal neuron: deep; Neocortical pyramidal neuron: superficial;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	MATLAB;
Model Concept(s):	Activity Patterns; Connectivity matrix; Laminar Connectivity;
Implementer(s):

Search NeuronDB for information about: Neocortical pyramidal neuron: deep; Neocortical pyramidal neuron: superficial;

Model files

Help downloading and running models

mhconmatvalues20100928_octave.m

mhconmatvalues20100928.m

This is the model for the associated paper:

PLoS Biol. 2011 Jan 4;9(1):e1000572.  Laminar analysis of excitatory
local circuits in vibrissal motor and sensory cortical areas. Hooks
BM, Hires SA, Zhang YX, Huber D, Petreanu L, Svoboda K, Shepherd GM.

Model is the excitatory->excitatory circuit of three cortical areas
(vM1, vS1, and S2) presented on a neuron or laminar basis (six
matrices).

The M-file is a text file from the supplemental info (S1), which is
simply the values used for the connectivity matrices of figure 7 (if
you run the M-file in matlab, it plots them as well as importing them
as variables).

Usage: start matlab and then type mhconmatvalues20100928 at the
command line.  This will reproduce panels b, c, e, f, h, and i in
Figure 7 of the associated paper:

7b: 
7c: 
7e: 
7f: 
7h: 
7i: 

An octave (free version of matlab) version,
mhconmatvalues20100928_octave.m, is also supplied by the ModelDB
Administrator.

A related model for somatic M1, mapped in comparable fashion in Weiler
et al (2008), is available at:

http://senselab.med.yale.edu/ModelDB/ShowModel.asp?model=114655

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