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Gamma and theta rythms in biophysical models of hippocampus circuits (Kopell et al. 2011)
Accession: 138421
" ... the main rhythms displayed by the hippocampus, the gamma (30–90 Hz) and theta (4–12 Hz) rhythms. We concentrate on modeling in vitro experiments, but with an eye toward possible in vivo implications. ... We use simpler biophysical models; all cells have a single compartment only, and the interneurons are restricted to two types: fast-spiking (FS) basket cells and oriens lacunosum-moleculare (O-LM) cells. ... , we aim not so much at reproducing dynamics in great detail, but at clarifying the essential mechanisms underlying the production of the rhythms and their interactions (Kopell, 2005). ..."
References:
1. Tort AB, Rotstein HG, Dugladze T, Gloveli T, Kopell NJ (2007) On the formation of gamma-coherent cell assemblies by oriens lacunosum-moleculare interneurons in the hippocampus. Proc Natl Acad Sci U S A 104:13490-5 [PubMed]
2. Gloveli T, Dugladze T, Rotstein HG, Traub RD, Monyer H, Heinemann U, Whittington MA, Kopell N (2005) Orthogonal arrangement of rhythm-generating microcircuits in the hippocampus. Proc Natl Acad Sci U S A 102:13295-300 [PubMed]
3. Kopell N, Borgers C, Pervouchine D, Malerba P, Tort ABL (2010) Gamma and theta rhythms in biophysical models of hippocampal circuits Hippocampal Microcircuits: A Computational Modeller`s Resource Book. Ch. 15., Cutsuridis V, Graham BF, Cobb S, Vida I, ed.
Citations  Citation Browser
Model Information (Click on a link to find other models with that property)
Model Type:  Network; Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  Hippocampus;
Cell Type(s):  CA1 pyramidal neuron; CA3 pyramidal neuron; CA1 oriens alveus interneuron;  Neocortical Fast Spiking (FS) interneuron;
Channel(s):  I Na,t; I K;  
Gap Junctions:  
Receptor(s):  GabaA; AMPA;
Gene(s):  
Transmitter(s):  
Simulation Environment:  MATLAB (web link to model);
Model Concept(s):  Oscillations;
Implementer(s):  
Search NeuronDB for information about:  CA1 pyramidal neuron; CA3 pyramidal neuron; CA1 oriens alveus interneuron; GabaA; AMPA; I Na,t; I K;
Model files (located externally to ModelDB) Help downloading and running models
These are web links to the models used in the publication:

N. Kopell, C. Borgers, D. Pervouchine, P. Malerba, and A. B.L.Tort.
Gamma and theta rhythms in biophysical models of hippocampal circuits.
Hippocampal Microcircuits: A Computational Modeller's Resource Book.
Eds. V. Cutsuridis, B.P. Graham, S. Cobb, I. Vida. Springer 2010. Ch.
15.

Click on these links to download matlab code for figures:
Fig. 1,
Fig. 2, and 
Figs. 3 and 4.

In figures 3 and 4 of this chapter we basically reproduce the
highlights of

Gloveli, T., Dugladze, T., Rotstein, H. G., Traub, R. D., Monyer, H.,
Heinemann, U., Whittington, M. A., and Kopell, N. J. 2005b. Orthogonal
arrangement of rhythm-generating microcircuits in the
hippocampus. Proc Natl Acad Sci USA, 102(37), 13295-13300.

Tort, A. B. L., Rotstein, H. G., Dugladze, T., Gloveli, T., and
Kopell, N. J. 2007. On the formation of gamma-coherent cell assemblies
by oriens lacunosum-moleculare interneurons in the hippocampus.
Proc Natl Acad Sci USA, 104(33), 13490-13495.

Usage:

Start matlab and then in the matlab command prompt: change directory
("cd" command) to where you extracted the above archives.  Further
change directory to the particular figure folder you wish to generate
and then type the name of a script like:

generate_Figure_1

(You can use the "ls" or "dir" command to see which programs are in
the current directory).

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