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Single neuron with ion concentrations to model anoxic depolarization (Zandt et al. 2011)
Accession: 139266
A minimal single neuron model, including changing ion concentrations and homeostasis mechanisms. It shows the sudden depolarization that occurs after prolonged anoxia/ischemia.
Reference: Zandt BJ, ten Haken B, van Dijk JG, van Putten MJAM (2011) Neural Dynamics during Anoxia and the "Wave of Death" PLoS ONE 6(7):e22127
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Model Information (Click on a link to find other models with that property)
Model Type:  Neuron or other electrically excitable cell;
Brain Region(s)/Organism:  
Cell Type(s):   Hodgkin-Huxley neuron;
Channel(s):  I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak;  
Gap Junctions:  
Receptor(s):  
Gene(s):  
Transmitter(s):  
Simulation Environment:  
Model Concept(s):  Anoxic depolarization;
Implementer(s):  Zandt, Bas-Jan [b.zandt at utwente.nl];
Search NeuronDB for information about:  I Na,t; I K; I K,leak; Na/K pump; I Cl, leak; I Na, leak;
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readme.txt
mainmodel.m
runmodel.m
                            
Matlab simulation of a single neuron with dynamic ion concentrations
It shows the sudden depolarization that can be observed when a neuron is not supplied with energy (ischemia).

code by Bas-Jan Zandt, b.zandt@utwente.nl
from the paper:
Neural dynamics during anoxia and the ``Wave of Death'' (http://dx.plos.org/10.1371/journal.pone.0022127)

partially based on Cressman et al., 2009, The influence of sodium and potassium dynamics
on excitability, seizures, and the stability of persistent states
J Comput Neurosci 26: 159–170


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