ModelDB: Biophysically detailed model of the mouse sino-atrial node cell (Kharche et al. 2011)

Biophysically detailed model of the mouse sino-atrial node cell (Kharche et al. 2011)

Accession: 141274

This model is developed to study the role of various electrophysiological mechanisms in generating cardiac pacemaking action potentials (APs).The model incorporates membrane ionic currents and intracellular mechanisms contributing to spontaneous mouse SAN APs. The model was validated by testing the functional roles of individual membrane currents in one and multiple parameter analyses.The roles of intracellular Ca2+-handling mechanisms on cardiac pacemaking were also investigated in the model.
Reference: Kharche S, Yu J, Lei M, Zhang H (2011) A mathematical model of action potentials of mouse sinoatrial node cells with molecular bases. Am J Physiol Heart Circ Physiol 301:H945-63 [PubMed]

Citations Citation Browser

Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Cardiac atrial cell;
Channel(s):	I N; I K; I Sodium; I Calcium; I Potassium; I_HERG; Na/Ca exchanger; KCNQ1; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):	Nav1.1 SCN1A; Nav1.2 SCN2A; HERG KCNH2; Cav3.1 CACNA1G; Cav1.3 CACNA1D; Cav1.2 CACNA1C;
Transmitter(s):
Simulation Environment:	C or C++ program;
Model Concept(s):	Action Potential Initiation; Oscillations; Action Potentials; Calcium dynamics; Cardiac pacemaking;
Implementer(s):	Kharche, Sanjay ;

Search NeuronDB for information about: I N; I K; I Sodium; I Calcium; I Potassium; I_HERG; Na/Ca exchanger; KCNQ1; Na/K pump;

Model files

Help downloading and running models

This is the readme for the model associated with the paper:

Kharche S, Yu J, Lei M, Zhang H (2011) A mathematical model of action
potentials of mouse sinoatrial node cells with molecular bases.
Am J Physiol Heart Circ Physiol 301:H945-63

These model files were contributed by Sanjay Kharche

Use:

This is a standard C program that should work with most compilers.  To
compile with linux type

gcc -lm Kharche_SAN.c

to run type:
./a.out > stdout.txt

The program will write a voltage trajectory, mousesan.dat, simulating
the mouse SAN cells.  This trajectory contains (the start of the file)
waveforms similar to the figure 2A:



and (the whole file) figure 3B in the paper:

ModelDB Home SenseLab Home Help
Questions, comments, problems? Email the ModelDB Administrator
How to cite ModelDB
This site is Copyright 2012 Shepherd Lab, Yale University