ModelDB: Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985)

Cardiac action potentials and pacemaker activity of sinoatrial node (DiFrancesco & Noble 1985)

Accession: 144520

"Equations have been developed to describe cardiac action potentials and pacemaker activity. The model takes account of extensive developments in experimental work ..."
Reference: DiFrancesco D, Noble D (1985) A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philos Trans R Soc Lond B Biol Sci 307:353-98 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Cardiac atrial cell; Cardiac ventricular cell;
Channel(s):	I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potentials;
Implementer(s):	Gannier, Francois [francois.gannier at univ-tours.fr];

Search NeuronDB for information about: I Na,t; I K; I h; I Calcium; I Potassium; Na/Ca exchanger; Na/K pump;

Model files

Help downloading and running models

This model reproduces the cardiac action potentials and pacemaker
activity of a mammalian cell of the sinoatrial node.

It is based on the paper by :

DiFrancesco D & Noble D (1985) A model of cardiac electrical activity
incorporating ionic pumps and concentration changes.
Phil. Trans. R. Soc. Lond. B 307:353-398
[PubMed]

implemented and modified for Neuron by Francois E. Gannier
	from University of Tours - FRANCE
	Physiologie des Cellules Cardiaques et Vasculaires
	email address: francois.gannier@univ-tours.fr

It was the first model to incorporate the external and internal
concentration changes and has been very influential in directing
modeling efforts.

To run the simulation auto-launch the model from modeldb or download
and extract the archive and then compile the mod files under:

unix/linux:
-----------
type nrnivmodl in the DiFrancescoNoble1985 folder and then
nrngui mosinit.hoc

mswin:
------
run mknrndll and then double click on mosinit.hoc

MAC OS X:
--------
Drag and drop the DiFrancescoNoble1985 folder onto the mknrndll icon.  
Drag and drop the mosinit.hoc file onto the nrngui icon.

Once the simulation starts it recreates the Fig. 6 of the original
paper:

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