This model reproduces the cardiac action potentials and pacemaker
activity of a mammalian cell of the sinoatrial node.
It is based on the paper by :
DiFrancesco D & Noble D (1985) A model of cardiac electrical activity
incorporating ionic pumps and concentration changes.
Phil. Trans. R. Soc. Lond. B 307:353-398
implemented and modified for Neuron by Francois E. Gannier
from University of Tours - FRANCE
Physiologie des Cellules Cardiaques et Vasculaires
email address: firstname.lastname@example.org
It was the first model to incorporate the external and internal
concentration changes and has been very influential in directing
To run the simulation auto-launch the model from modeldb or download
and extract the archive and then compile the mod files under:
type nrnivmodl in the DiFrancescoNoble1985 folder and then
run mknrndll and then double click on mosinit.hoc
MAC OS X:
Drag and drop the DiFrancescoNoble1985 folder onto the mknrndll icon.
Drag and drop the mosinit.hoc file onto the nrngui icon.
Once the simulation starts it recreates the Fig. 6 of the original
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