| Olfactory Bulb Network (Davison et al 2003) |
| Accession: 2730 |
A biologically-detailed model of the mammalian olfactory bulb, incorporating
the mitral and granule cells and the dendrodendritic synapses between them.
The results of simulation experiments with electrical stimulation agree
closely in most details with published experimental data. The model predicts
that the time course of dendrodendritic inhibition is dependent on the
network connectivity as well as on the intrinsic parameters of the synapses.
In response to simulated odor stimulation, strongly activated mitral cells
tend to suppress neighboring cells, the mitral cells readily synchronize
their firing, and increasing the stimulus intensity increases the degree of
synchronization. For more details, see the reference below.
Reference: Davison AP, Feng J, Brown D (2003) Dendrodendritic inhibition and simulated odor responses in a detailed olfactory bulb network model. J Neurophysiol 90:1921-1935 [PubMed] |
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| Search NeuronDB for information about: Olfactory bulb mitral cell; Olfactory bulb granule cell; GabaA; AMPA; NMDA; I Na,t; I L high threshold; I A; I K; I K,leak; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Gaba; Glutamate; |
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| This is a model of the mammalian olfactory bulb for the
NEURON simulator. The model contains only mitral and
granule cells.
A full description may be found in:
Davison A.P., Feng J. and Brown D. (2003) Dendrodendritic
inhibition and simulated odor responses in a detailed
olfactory bulb network model. J. Neurophysiol. In Press.
It is intended that the properties of the network can be
explored by changing the files parameters_<xxx>.hoc and
experiment_<xxx>.hoc. It should not be necessary to change
the other files.
After compiling the mod files, start the simulation by
running init.hoc Type show_results() if after running the
odour stimulus simulation the mitral cell spike time
histogram graph is empty.
For more information, contact andrew.davison@iaf.cnrs-gif.fr
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