README for the models associated with the paper:
Saraga F, Wu CP, Zhang L, Skinner FK. Active Dendrites and Spike Propagation
in Multi-compartment Models of Oriens-Lacunosum/Moleculare Hippocampal Interneurons.
J Physiol. 2003 Aug 15
It is well known that interneurons are heterogeneous in their morphologies, biophysical
properties, pharmacological sensitivities and electrophysiological responses, but it is
unknown how best to understand this diversity. Given their critical roles in shaping brain
output, it is important to try to understand the functionality of their computational
characteristics. To do this, we focus on specific interneuron subtypes. In particular, it
has recently been shown that long-term potentiation is induced specifically on
oriens-lacunosum/moleculare (O-LM) interneurons in hippocampus CA1 and that the same cells
contain the highest density of dendritic sodium and potassium conductances measured to date.
We create multi-compartment models of an O-LM hippocampal interneuron using passive
properties, channel kinetics, densities and distributions specific to this cell type, and
explore its signaling characteristics. We find that spike initiation depends on both
location and amount of input, as well as the intrinsic properties of the interneuron. Distal
synaptic input always produces strong back-propagating spikes whereas proximal input could
produce both forward and back-propagating spikes depending on the input strength. We
speculate that the highly active dendrites of these interneurons endow them with a
specialized function within the hippocampal circuitry by allowing them to regulate direct
and indirect signaling pathways within the hippocampus.
This model can be auto-launched from modeldb or run by starting the mosinit.hoc with:
or double clicking on the mosinit.hoc file
after the mod files have been compiled (nrnivmodl compiles in unix, mknrndll in mswin, mac)
Select a figure by clicking on a figure name.