ModelDB: Olfactory Mitral Cell (Shen et al 1999)

Olfactory Mitral Cell (Shen et al 1999)

Accession: 3342

Mitral cell model with standard parameters for the paper: Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L. (1999) Computational Analysis of Action Potential Initiation in Mitral Cell Soma and Dendrites Based on Dual Patch Recordings. Journal of Neurophysiology 82:3006. Contact Michael.Hines@yale.edu if you have any questions about the implementation of the model.
Reference: Shen GY, Chen WR, Midtgaard J, Shepherd GM, Hines ML (1999) Computational analysis of action potential initiation in mitral cell soma and dendrites based on dual patch recordings. J Neurophysiol 82:3006-20 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Olfactory bulb mitral cell; Myelinated neuron;
Channel(s):	I Na,t; I K; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment:	Neuron;
Model Concept(s):	Action Potential Initiation; Dendritic Action Potentials; Parameter Fitting; Active Dendrites;
Implementer(s):	Hines, Michael [Michael.Hines at Yale.edu];

Search NeuronDB for information about: Olfactory bulb mitral cell; I Na,t; I K; I Sodium; I Potassium;

Model files

Help downloading and running models

Mitral cell model with standard parameters for the paper:

Shen, G.Y., Chen, W. R., Midtgaard, J., Shepherd, G.M., and Hines, M.L.
(1999)
Computational Analysis of Action Potential Initiation in Mitral
Cell Soma and Dendrites Based on Dual Patch Recordings.
Journal of Neurophysiology  82: 3006

Questions about how to use this simulation should be
directed to
	michael.hines@yale.edu

Running the model (execution of the mosinit.hoc file) will display
the data and simulation results as in  Fig 3 and 5.

The cell2 subdirectory contains cell data and simulation which shows
only a limited decrease in the action potential interval.
Running the model (cd cell2 and execute the mosinit.hoc file)
will display the data and simulation within a Multiple Run Fitter.

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