ModelDB: Enhanced Excitability in Hermissenda: modulation by 5-HT (Cai et al 2003)

Enhanced Excitability in Hermissenda: modulation by 5-HT (Cai et al 2003)

Accession: 34163

Serotonin (5-HT) applied to the exposed but otherwise intact nervous system results in enhanced excitability of Hermissenda type-B photoreceptors. Several ion currents in the type-B photoreceptors are modulated by 5-HT, including the A-type K+ current (IK,A), sustained Ca2+ current (ICa,S), Ca-dependent K+ current (IK,Ca), and a hyperpolarization-activated inward rectifier current (Ih). In this study,we developed a computational model that reproduces physiological characteristics of type B photoreceptors, e.g. resting membrane potential, dark-adapted spike activity, spike width, and the amplitude difference between somatic and axonal spikes. We then used the model to investigate the contribution of different ion currents modulated by 5-HT to the magnitudes of enhanced excitability produced by 5-HT. See paper for results and more details.
Reference: Cai Y, Baxter DA, Crow T (2003) Computational study of enhanced excitability in Hermissenda: membrane conductances modulated by 5-HT. J Comput Neurosci 15:105-21 [PubMed]

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Model Information (Click on a link to find other models with that property)

Model Type:	Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s):	Type B photoreceptor;
Channel(s):	I Na,t; I L high threshold; I N; I A; I K; I h; I K,Ca; I Calcium; I A, slow;
Gap Junctions:	Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):	Serotonin;
Simulation Environment:	SNNAP;
Model Concept(s):	Activity Patterns; Action Potentials; Invertebrate;
Implementer(s):	Cai, Yidao;

Search NeuronDB for information about: I Na,t; I L high threshold; I N; I A; I K; I h; I K,Ca; I Calcium; I A, slow; Serotonin;

Model files

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bph.trt_Ikcamod

bph_Ikcamod.smu

README.txt

This simulation reproduces the model published 
in:

Cai Y, Baxter DA, Crow T
Computational Study of Enhanced Excitability in Hermissenda:
Membrane Conductances Modulated by 5-HT
Journal of Computational Neuroscience 15, 105-121, 2003

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Start SNNAP (double click on the SNNAP.jar file)
click on "Run Simulation"
Then in the new window "File"->"Load Simulation"
browse to and load bph_mixmod.smu file to load a simulation
that creates a figure similar to Fig6C from the paper and click "Start"
See http://snnap.uth.tmc.edu/ to download SNNAP

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